And then there was [Colin Blakemore’s] rapier-sharp wit. We recall when a visiting professor, one of the many world-class neuroscientists to visit his laboratory, was having a birthday. At the time, one project in Colin’s laboratory involved studying how a subpopulation of callosal projecting layer 5 neocortical pyramidal neurons retract their dendritic tufts that reached to the pial surface during the first week of postnatal development in the mouse. Colin’s memorable message on the birthday card was “May your tuft never retract”!