… it’s a frightening reminder of the power of the brain. Our brains, when diseased, can kill us.

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No worst, there is none. Pitched past pitch of grief,

More pangs will, schooled at forepangs, wilder wring.

Comforter, where, where is your comforting?

Mary, mother of us, where is your relief?

My cries heave, herds-long; huddle in a main, a chief

Woe, wórld-sorrow; on an áge-old anvil wince and sing —

Then lull, then leave off. Fury had shrieked ‘No ling-

ering! Let me be fell: force I must be brief.”‘

    O the mind, mind has mountains; cliffs of fall

Frightful, sheer, no-man-fathomed. Hold them cheap

May who ne’er hung there. Nor does long our small

Durance deal with that steep or deep. Here! creep,

Wretch, under a comfort serves in a whirlwind: all

Life death does end and each day dies with sleep.

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David Foster Wallace, Infinite Jest:

[I]t was as if a large billowing shape came billowing out of some corner in my mind. I can be no more precise than to say large, dark, shape, and billowing, what came flapping out of some backwater of my psyche I had not the slightest inkling was there. … It was total psychic horror: death, decay, dissolution, cold empty black malevolent lonely voided space. … I simply could not live with how it felt. … I understood the term hell as of that summer day and that night in the sophomore dormitory. I understood what people meant by hell.

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It is a level of psychic pain wholly incompatible with human life as we know it. It is a sense of radical and thoroughgoing evil not just as a feature but as the essence of conscious existence. It is a sense of poisoning that pervades the self at the self’s most elementary levels. It is a nausea of the cells and soul. It is an unnumb intuition in which the world is fully rich and animate and un-map-like and also thoroughly painful and malignant and antagonistic to the self, which depressed self It billows on and coagulates around and wraps in Its black folds and absorbs into Itself, so that an almost mystical unity is achieved with a world every constituent of which means painful harm to the self. … It is also lonely on a level that cannot be conveyed….